Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD

Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD.

Bronchial hyperresponsiveness (BHR) is regarded as a hallmark of asthma, yet it is also present in a considerable number of chronic obstructive pulmonary disease (COPD) patients. Epidemiological studies have shown that BHR provides complementary information to forced expiratory volume in 1 s (FEV(1)) for development and progression of COPD. We hypothesised that the severity of BHR and its longi...

Effects of fluticasone propionate in COPD patients with bronchial hyperresponsiveness.

BACKGROUND Treatment of chronic obstructive pulmonary disease (COPD) with inhaled corticosteroids does not appear to be as effective as similar treatment of asthma. It seems that only certain subgroups of patients with COPD benefit from steroid treatment. A study was undertaken to examine whether inhaled fluticasone propionate (FP) had an effect on lung function and on indices of inflammation i...

Bronchial hyperresponsiveness: animal models and clinical aspects

The environmental disaster following flooding by red sludge in the Ajka region in Hungary poses a seriouspublic health threat with particular concern regarding the potentially adverse respiratory effects of theinhalation of red sludge dust (RSD). The respiratory consequences of the inhalation of RSD obtained fromfield samples were investigated in rats. Rats were either exposed to RS...

Bronchial Hyperresponsiveness in Asthma*

Measurement ofnonspecific bronchial hyperresponsiveness remains largely a research tool in asthma, and its usefulness in the assessment and management of asthma is poorly defined. We StUdied the relationship of bronchial hyperresponsiveness to the clinical severity of asthma in 54 asthmatic subjects. In order to find out whether measurement of bronchial hyperresponsiveness could be used to pred...

Resolution of Bronchial Hyperresponsiveness